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button Wet Nanomanufacturing
    button Materials Metrology with Microfluidics
  button Porous Protein Mimics
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  button SANS of Labeled SWNT Dispersions and Clusters
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button Quantification of Processing Flows
  button Real-Time Measurements of Extent of Exfoliation
  button Flow-Induced Structure in Micro-Confined Immiscible Polymer Blends
  button Frust-TIR: New Measurement Technique for Coating Kinetics
 

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Porous Protein Mimics
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Porous Protein Mimics Porous Protein Mimics
 

Introduction

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For advanced materials measuement, handling and production:
Need to sequester, recognize and transfer reactants and products.
Channels <----- Vessels
Drops and vesicles to reach a smaller scale efficiently <-----Vessels (Inspiration from biology)
Membrane channels
  • Key to vesicle function.
  • An ideal paradigm for nanomedicine. Need devices to interact with cells.
  • Protein channels have limited lifetime.
  • Potential applications: drug delivery, water purification, smart sensors, reaction process control and soft nanoparticle metrology.
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    Experimental Approach, Self Assembly

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  • Supramolecular chemistry
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    Supramolecular chemistry dipeptide chiral dendron
    dipeptide chiral dendron
  • Assembly of cylinders
    • Assembly of cylinders
     

    Results
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    Hexagonal array of pores
    Transmission electron microscopy: Direct determination of Fourier components (amplitude and phase) demonstrated that the cylindrical assemblies are tubular. 1.4 nm pore Proton transport through pore
    Transmission electron microscopy: Direct determination of Fourier components (amplitude and phase) demonstrated that the cylindrical assemblies are tubular. 1.4 nm pore
    		 Proton transport through pore
     
    Related cubic Structure
     

    Publications

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    "Self-Assembling Amphiphilic Dendritic Dipeptides that Mimic Helical Protein Pores," V. Percec, A. Dulcey, V. S. K. Balagurusamy, Y. Miura, J. Smidrkal, M. Perterca, S. Nummelin, U. Edlund, S. D. Hudson, P. A. Heiney, H. Duan, S. N. Magonov, S. A. Vinogradov, Nature, in press.
     

    Contributors:
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    S. D. Hudson, J. J. Kasianowicz (NIST, biotechnology), V. Percec (U.Penn)
     
     
     
     
    		 
    		 
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    Processing Characterization Group
    Polymers Division
    Materials Science and Engineering Laboratory
     
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